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Search Results for " galactosidase, α "

Targets Recommended: Others

13

抑制剂 & 化合物

3

天然产物

5

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T19139	4-Nitrophenyl α-D-galactopyranoside PNP-alpha-D-Gal,4-硝基苯-α-D-吡喃半乳糖苷,PNP-α-D-Gal	Others	Others
	4-Nitrophenyl α-D-galactopyranoside (PNP-alpha-D-Gal) 是 4-硝基苯基 (pNP) 糖吡喃糖苷的人工底物，可用于 α-半乳糖苷酶活性的检测。它用作底物能够显著增加 pNP 的释放量。
T76134	α-Galactosidase
	α-Galactosidase(EC 3.2.1.22)，即 α-半乳糖苷酶，是一种糖苷水解酶，广泛存在于动植物和微生物中，常用于生化研究。α-Galactosidase 可以催化 α-1,6 连接的末端半乳糖残基的水解，包括低聚半乳糖、半乳甘露聚糖和半乳糖脂。催化许多分解代谢过程，包括糖蛋白、糖脂和多糖的裂解。
T73615	β-Galactosidase
	β-Galactosidase，即 β-半乳糖苷酶，是一种糖苷水解酶，可水解半乳糖与其有机部分之间形成的 β-糖苷键。在大肠杆菌中，lacZ 基因是 β-半乳糖苷酶的结构基因，可作为诱导系统lac 操纵子的一部分。β-Galactosidase 可以水解乳糖形成葡萄糖和半乳糖，进入糖酵解；也可以催化乳糖转半乳糖基化为异乳糖；异乳糖可以裂解成单糖。
T19825	X-alpha-Gal	Others	Others
	X-alpha-Gal 是 α-半乳糖苷酶的底物。它用于区分酵母的α-半乳糖苷酶阳性菌株。
T37192	4-Methylumbelliferyl-α-D-Galactopyranoside 4MU-α-Gal	Others	Others
	4-Methylumbelliferyl-α-D-Galactopyranoside (4MU-α-Gal) (4-MU-α-Gal)是α-半乳糖苷酶的荧光底物。除了用于表征新的α-半乳糖苷酶外，4-MU-α-Gal 还用于评估与法布里病相关的α-半乳糖糖苷酶活性的缺乏。
T12038	Migalastat hydrochloride GR181413A hydrochloride,Migalastat HCl,GR181413A HCl	Others	Others
	Migalastat hydrochloride (GR181413A) 是一种可口服且具有有效和竞争性的 α-galactosidase A 抑制剂，可促进α-半乳糖苷酶A向溶酶体的运输，可用于研究法布里病。
T23987	DGJ-pFPhT DGJ pFPhT
	DGJ-pFPhT is a ligand of human α-galactosidase A.
T32923	Lucerastat NBDGJ
	Lucerastat is a very effective and selective α-gal A (α-D-galactosidase) inhibitor for the treatment of lipid storage diseases and Fabry disease.
T71481	Migalastat GR181413A free base
	Migalastat (GR181413A free base) 是一种具有口服活性和竞争性的α-galactosidase A 抑制剂，对人α-Gal A 的IC50值为 0.04 μM。
T37439	C18 Globotriaosylceramide (d18:1/18:0)
	C18 globotriaosylceramide is an endogenous sphingolipid found in mammalian cell membranes that is synthesized from lactosylceramide . It inhibits aggregation of human neutrophils induced by phorbol 12-myristate 13-acetate (PMA; 10008014) when used at a concentration of 1 μM. C18 globotriaosylceramide acts as a receptor for Shiga toxin in B cell-derived Raji cells and THP-1 monocytes. It accumulates in the brain, heart, kidney, liver, lung, and spleen in a mouse model of Fabry disease, a lysosoma...
T37843	Australine (hydrochloride)
	Australine is a pyrrolizidine alkaloid originally isolated fromC. australethat has enzyme inhibitory activities.1,2,3It is an inhibitor of glucoamylase (IC50= 5.8 μM) that also inhibits glucosidase I, sucrase, maltase, andA. nigerα-glucosidase (IC50s = 20, 28, 35, and 28 μM, respectively).2,3Australine is selective for these enzymes over glucosidase II, α- and β-mannosidase, and α- and β-galactosidase up to 500 μM, β-glucosidase, with only 5% inhibition at 66 μM, as well as isomaltase and trehal...
T36185	Globotriaosylceramides (hydroxy) (porcine)
	Globotriaosycleramides are glycosphingolipids found in mammalian cell membranes that are synthesized from lactosylceramides . They act as receptors for Shiga and Shiga-like toxins in vitro and in vivo. Globotriaosylceramides accumulate in endothelial cells, pericytes, vascular smooth muscle cells, renal epithelial cells, dorsal ganglia neuronal cells, and myocardial cells in patients with Fabry disease, a lysosomal storage disorder characterized by a deficiency in the enzyme α-galactosidase A. G...
T36186	Globotriaosylceramides (porcine)
	Globotriaosycleramides are glycosphingolipids found in mammalian cell membranes that are synthesized from lactosylceramides . They act as receptors for Shiga and Shiga-like toxins in vitro and in vivo. Globotriaosylceramides accumulate in endothelial cells, pericytes, vascular smooth muscle cells, renal epithelial cells, dorsal ganglia neuronal cells, and myocardial cells in patients with Fabry disease, a lysosomal storage disorder characterized by a deficiency in the enzyme α-galactosidase A. G...

化合物

4-Nitrophenyl α-D-galactopyranoside

Cat.No: T19139

Synonym: PNP-alpha-D-Gal,4-硝基苯-α-D-吡喃半乳糖苷,PNP-α-D-Gal

Target: Others

α-Galactosidase

Cat.No: T76134

β-Galactosidase

Cat.No: T73615

Cat.No: T19825

Target: Others

4-Methylumbelliferyl-α-D-Galactopyranoside

Cat.No: T37192

Synonym: 4MU-α-Gal

Target: Others

Migalastat hydrochloride

Cat.No: T12038

Synonym: GR181413A hydrochloride,Migalastat HCl,GR181413A HCl

Target: Others

Cat.No: T23987

Synonym: DGJ pFPhT

Cat.No: T32923

Synonym: NBDGJ

Cat.No: T71481

Synonym: GR181413A free base

C18 Globotriaosylceramide (d18:1/18:0)

Cat.No: T37439

Australine (hydrochloride)

Cat.No: T37843

Globotriaosylceramides (hydroxy) (porcine)

Cat.No: T36185

Globotriaosylceramides (porcine)

Cat.No: T36186

Cat. No.	Product Name	Target	Signaling Pathways
T8144	Raffinose Melitose,Melitriose,棉子糖	Others; Endogenous Metabolite	Metabolism; Others
	Raffinose (Melitriose) 是不能够消化的短链寡糖，是由半乳糖，葡萄糖和果糖组成的三糖，能够在许多植物中找到。它能够被 α-半乳糖苷酶 (α-GAL) 水解为 D-半乳糖和蔗糖。
T5809	Stachyose hydrate Stachyose,水苏糖	Others	Others
	Stachyose hydrate 是一种能够增强有益细菌的生长和活性的益生元。它具有降血糖作用，能够调节肠道微生物而改善炎症。
T37291	Lyso-Globotriaosylceramide (d18:1) Lyso-Globotriaosylceramide (d18:1)
	Lyso-globotriaosylceramide is a form of globotriaosylceramide that is lacking the fatty acyl group. It binds to Shiga toxin 1 (Stx1) in the presence of cholesterol and phosphatidylcholine but does not bind Stx2. It also reduces viability and aggregation of human neutrophils induced by phorbol 12-myristate 13-acetate when used at concentrations of 50 and 1 μM, respectively. Lyso-globotriaosylceramide accumulates in the brain, heart, kidney, liver, lung, and spleen in a mouse model of Fabry diseas...

天然产物

Cat.No: T8144

Synonym: Melitose,Melitriose,棉子糖

Target: Others, Endogenous Metabolite

Stachyose hydrate

Cat.No: T5809

Synonym: Stachyose,水苏糖

Target: Others

Lyso-Globotriaosylceramide (d18:1)

Cat.No: T37291

Synonym: Lyso-Globotriaosylceramide (d18:1)

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01727	GLA/alpha-Galactosidase A Protein, Human, Recombinant (His) GLA/α-Galactosidase A Protein,galactos...	Human	HEK293 Cells
	GLA/alpha-Galactosidase A Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 46.8 kDa and the accession number is P06280.
TMPY-02857	GLA/alpha-Galactosidase A Protein, Mouse, Recombinant (His) galactosidase, alpha,Ags,galactosidase,	Mouse	HEK293 Cells
	GLA/alpha-Galactosidase A Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 45.6 kDa and the accession number is Q8BGZ6.
TMPJ-00728	Beta-galactosidase Protein, E. coli, Recombinant Beta-gal,Beta-galactosidase,lacZ,β-galactosidas...	E. coli	E. coli
	β-galactosidase is an exoglycosidase which hydrolyzes the β-glycosidic bond formed between a galactose and its organic moiety. It may also cleave fucosides and arabinosides but with much lower efficiency. β-galactosides include carbohydrates containing galactose where the glycosidic bond lies above the galactose molecule. Substrates of different β-galactosidases include ganglioside GM1, lactosylceramides, lactose, and various glycoproteins. It is an essential enzyme in the human body. Deficienci...
TMPH-00129	Probable Alpha Galactosidase B Protein, Aspergillus niger, Recombinant (His)	Aspergillus niger	P. pastoris (Yeast)
	Hydrolyzes a variety of simple alpha-D-galactoside as well as more complex molecules such as oligosaccharides and polysaccharides. Probable Alpha Galactosidase B Protein, Aspergillus niger, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 48.7 kDa and the accession number is A2QEJ9.
TMPK-00944	ST3GAL4 Protein, Human, Recombinant (HA, His) STZSIAT4,ST-4,SIAT4,ST3GAL4,SAT3,CGS23,SIAT4C,Gal-NAc 6S,NAN...	Human	HEK293 Cells
	ST3GAL4 gene expression is altered in different cancer types, including cervical cancer. Several mRNA transcripts have been reported for this gene. ST3GAL4 encodes for β‑galactosidase α‑2,3‑sialyltransferase 4, involved in the biosynthesis of the tumour antigens sLe(x) and sulfo‑sLe(x).

重组蛋白

GLA/alpha-Galactosidase A Protein, Human, Recombinant (His)

Cat.No: TMPY-01727

Species: Human

Expression System: HEK293 Cells

GLA/alpha-Galactosidase A Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02857

Species: Mouse

Expression System: HEK293 Cells

Beta-galactosidase Protein, E. coli, Recombinant

Cat.No: TMPJ-00728

Species: E. coli

Expression System: E. coli

Probable Alpha Galactosidase B Protein, Aspergillus niger, Recombinant (His)

Cat.No: TMPH-00129

Species: Aspergillus niger

Expression System: P. pastoris (Yeast)

ST3GAL4 Protein, Human, Recombinant (HA, His)

Cat.No: TMPK-00944

Species: Human

Expression System: HEK293 Cells

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